Ribosomal Ribonucleic Acid Synthesis by Virulent Treponema pallidum
نویسندگان
چکیده
منابع مشابه
Capacity of virulent Treponema pallidum (Nichols) for deoxyribonucleic acid synthesis.
Treponema pallidum (Nichols) was extracted from infected rabbit tissue, and cell lysates were prepared for monitoring thymidine kinase and deoxyribonucleic acid polymerase activities. No thymidine kinase could be demonstrated in preparations of T. pallidum or the cultivable T. phagedenis biotype Reiter. Significant levels of deoxyribonucleic acid polymerase were detected in both treponemal samp...
متن کاملParasitism by virulent Treponema pallidum of host cell surfaces.
The interaction between virulent Treponema pallidum extracted from infected rabbit testes and animal cells in culture was examined. The extent of treponemal attachment to monolayers of normal rabbit testicular and HEp-2 cells was dependent upon the incubation temperature and retained motility of the spirochetes. The specific orientation of treponemes to host cell surfaces was demonstrated by da...
متن کاملEffect of gentamicin sulphate on avirulent and virulent Treponema pallidum.
The bactericidal activity of the aminoglycoside gentamicin has been demonstrated against a broad spectrum of bacteria (Jackson and Finland, 1969). This spectrum included Neisseria gonorrhoeae (Waitz and Weinstein, 1969); however, before gentamicin is used for the treatment of gonorrhoea, its effect on Treponema pallidum should be investigated to determine whether it can delay or mask the develo...
متن کاملMolecular specificities of monoclonal antibodies directed against virulent Treponema pallidum.
Radioimmunoprecipitation (RIP) and Western blot analyses with specific anti-Treponema pallidum subsp. pallidum monoclonal antibodies were used to identify antigens with apparent masses of 102, 84, 54, 53, 52, 47, 32, 29, and 24 kilodaltons (kDa). Cross-reactivity of these antibodies with T. pallidum subsp. pertenue antigens and lack of cross-reactivity with T. phagedenis biotype Reiter, T. vinc...
متن کاملAttachment of virulent Treponema pallidum to human mononuclear phagocytes.
The predominant phagocyte in established human syphilitic lesions is the mononuclear phagocyte. As these leucocytes may be important in immunity to Treponema pallidum, the initial interaction between human phagocytes and pathogenic T. pallidum (Nichols strain) was studied in vitro. Motile, virulent T. pallidum attach to the surface membrane of phagocytes but are not ingested by these cells. Hea...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1978
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.19.3.854-860.1978